Down syndrome Collection

Down syndrome is the most frequent genetic cause of human birth defects and intellectual disability, caused by trisomy of human chromosome 21 (Ts21).  This iPSC collection serves as a model for Down syndrome and consists of both Ts21 and isogenic control iPSCs.  iPSCs were created by reprogramming of two human Ts21 fibroblast lines. One of the fibroblast lines was mosaic for Ts21 and yielded both Ts21 (DS1, DS4) and isogenic euploid control (DS2U) lines. Ts21 iPSCs (2DS3) were generated from the other Ts21 fibroblast line.

The publication describing this collection of iPSCs may be found here

Cell Lines 4 Cell Lines
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Cell Line Cell Line Alias Cell Type Disease Genetic Alteration/Mutation Sex Age at Collection Ethnicity Genetically Related Cell Lines dbGaP Data
UWWC1-2DS3 2DS3 Human iPS Down syndrome, Trisomy 21 47,XY,+21 (Trisomy 21) Male 1 year No No
UWWC1-DS1 DS1 Human iPS Down syndrome, Trisomy 21 47,XY,+21 (Trisomy 21) Male 1 month No No
UWWC1-DS2U DS2U Human iPS None reported Male 1 month No No
UWWC1-DS4 DS4 Human iPS Down syndrome, Trisomy 21 47,XY,+21 (Trisomy 21) Male 1 month No No
Cell Lines 4 Cell Lines
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