Platelet Aggregation (Dr. Lewis Becker, The Johns Hopkins University)

About Becker Lab’s Next Gen Cell Lines

This collection, from Dr. Lewis Becker (The Johns Hopkins University), was generated to enable the study of the genetic basis of human variation in native platelet function and platelet responsiveness to aspirin. The iPS cell lines from this study are included within this collection.

This collection contains 198 human induced pluripotent stem cell lines derived under highly efficient clinically compliant conditions. The cell lines are comprised of healthy brothers, sisters, and offspring of index cases and siblings of persons of early onset coronary disease (< 60 years of age). None of the subjects were affected with clinical coronary disease, stroke, or other overt vascular disease phenotypes at the time of the study. Pedigrees are detailed in the “Genetically Related Cell Lines” field of each cell line’s web page.  The ages of donors range from 28 to 86 and ethnicities include Caucasian and African American. 

About the Next Generation Genetic Association Studies (Next Gen) Program         

These cell lines were created as Next Generation Genetic Association Studies (Next Gen) Program, which was a five-year, $80 million program to investigate functional genetic variation in humans by assessing cellular profiles that are surrogates for disease phenotypes. To achieve this, researchers from multiple institutions across the U.S. were awarded grants to derive iPS cell lines from more than 1,500 individuals representing various conditions as well as healthy controls for use in functional genomic (‘disease in a dish’) research. This extensive panel includes a diverse set of age, gender and ethnic backgrounds, and therefore will be an invaluable tool for evaluations across demographics. Further enhancing the utility of these cell lines are data sets such as phenotyping, GWAS, genome sequencing, gene expression and -omics analyses (e.g., lipidomic, proteomic, methylomic) that will be made available with the cell lines.

Cell Lines 198 Cell Lines
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Cell Line Cell Line Alias Cell Type Disease Genetic Alteration/Mutation Sex Age at Collection Ethnicity Genetically Related Cell Lines dbGaP Data
JHU001i P001 Human iPS None reported Female 29 years Caucasian No Yes
JHU002i-1 P002A Human iPS None reported Female 63 years African American No Yes
JHU004i-2 P004B Human iPS None reported Male 61 years African American No Yes
JHU012i-2 P012B Human iPS None reported Male 49 years African American No Yes
JHU013i-2 P013B Human iPS None reported Female 52 years African American No Yes
JHU017i P017 Human iPS None reported Female 46 years African American No Yes
JHU018i P018 Human iPS None reported Male 59 years African American No Yes
JHU019i P019 Human iPS None reported Female 35 years African American No Yes
JHU022i P022 Human iPS None reported Male 49 years African American No Yes
JHU023i P023 Human iPS None reported Female 50 years African American No Yes
Cell Lines 198 Cell Lines
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