NHLBI Next Gen – QT Interval and ECG Cardiac Traits (Dr. Kelly Frazer, University of California San Diego)

About Frazer Lab’s Next Gen Cell Lines

This collection, from Dr. Kelly Frazer (UC San Diego), was generated for regulatory genomic studies in iPS cells and derived cardiomyocytes.  The iPS cell lines from these studies are included within this collection.  

This collection contains 222 cell lines, including 41 family groups within this study and 13 sets of twins.  (Pedigrees are detailed in “Genetically Related Cell Lines” of each cell line’s web page.)  Individuals giving rise to iPSC lines were from the UCSD Twin/Sibling/Pedigree (TSP) cohort, and were re-consented for this study.  Disease states for the donors include long QT Syndrome, ECG traits (cardiac arrhythmias, sudden cardiac death), as well as individuals with no reported diagnoses.  The age of donors range from 9-88 and ethnicities include European, African American, and Asian. 

About the Next Generation Genetic Association Studies (Next Gen) Program         

These cell lines were created as Next Generation Genetic Association Studies (Next Gen) Program, which was a five-year, $80 million program to investigate functional genetic variation in humans by assessing cellular profiles that are surrogates for disease phenotypes. To achieve this, researchers from multiple institutions across the U.S. were awarded grants to derive iPS cell lines from more than 1,500 individuals representing various conditions as well as healthy controls for use in functional genomic (‘disease in a dish’) research. This extensive panel includes a diverse set of age, gender and ethnic backgrounds, and therefore will be an invaluable tool for evaluations across demographics. Further enhancing the utility of these cell lines are data sets such as phenotyping, GWAS, genome sequencing, gene expression and -omics analyses (e.g., lipidomic, proteomic, methylomic) that will be made available with the cell lines.

Cell Lines 220 Cell Lines
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Cell Line Cell Line Alias Cell Type Disease Genetic Alteration/Mutation Sex Age at Collection Ethnicity Genetically Related Cell Lines dbGaP Data
UCSD001i-5-1 iPSCORE_5_1 Human iPS None reported Female 43 years Caucasian > European Yes Yes
UCSD002i-16-1 iPSCORE_16_1 Human iPS None reported Male 51 years Asian > Indian Yes Yes
UCSD003i-16-2 iPSCORE_16_2 Human iPS None reported Female 47 years Asian > Indian Yes Yes
UCSD004i-42-1 iPSCORE_42_1 Human iPS Hypertrophic Cardiomyopathy Female 61 years Caucasian > European No Yes
UCSD005i-43-1 iPSCORE_43_1 Human iPS Left ventricular non-compaction Male 18 years African American No Yes
UCSD006i-21-1 iPSCORE_21_1 Human iPS None reported Male 55 years Caucasian > European Yes Yes
UCSD007i-21-2 iPSCORE_21_2 Human iPS None reported Female 47 years Caucasian > European Yes Yes
UCSD008i-44-1 iPSCORE_44_1 Human iPS Left ventricular non-compaction Male 37 years Caucasian > European No Yes
UCSD009i-5-2 iPSCORE_5_2 Human iPS None reported Female 10 years Caucasian > European Yes Yes
UCSD010i-5-3 iPSCORE_5_3 Human iPS None reported Male 9 years Caucasian Yes Yes
Cell Lines 220 Cell Lines
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