NHLBI Next Gen – Lipid Conditions (Dr. Daniel Rader, University of Pennsylvania)

About Rader Lab’s Next Gen Cell Lines

This collection, from Dr. Daniel Rader (University of Pennsylvania), was generated with the goal of creating a library of iPS cell lines and iPS-derived hepatocytes of differing genotype for use in metabolic profiling and interrogating lipid phenotypes.  The iPS cell lines from these studies are included within this collection.  Seminal publications by Dr. Daniel Rader regarding these cell lines are in press.

This collection contains 169 cell lines.  Individuals giving rise to iPSC lines were from the “GENE Study”, and includes individuals with Homozygous Familial Hypercholesterolemia, Tangier Disease, Abetalipoproteinemia, and Hyperalphalipoproteinemia as well as individuals with no reported diagnoses.  The age of donors range from 20-66 and various ethnicities. 

Please also see Lipid Serum Measurements and Blood Type for these cell lines.

About the Next Generation Genetic Association Studies (Next Gen) Program         

These cell lines were created as Next Generation Genetic Association Studies (Next Gen) Program, which was a five-year, $80 million program to investigate functional genetic variation in humans by assessing cellular profiles that are surrogates for disease phenotypes. To achieve this, researchers from multiple institutions across the U.S. were awarded grants to derive iPS cell lines from more than 1,500 individuals representing various conditions as well as healthy controls for use in functional genomic (‘disease in a dish’) research. This extensive panel includes a diverse set of age, gender and ethnic backgrounds, and therefore will be an invaluable tool for evaluations across demographics. Further enhancing the utility of these cell lines are data sets such as phenotyping, GWAS, genome sequencing, gene expression and -omics analyses (e.g., lipidomic, proteomic, methylomic) that will be made available with the cell lines.

Cell Lines 169 Cell Lines
Items per page 10 20 Show All >>
Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17


Cell Line Cell Line Alias Cell Type Disease Genetic Alteration/Mutation Sex Age at Collection Ethnicity Genetically Related Cell Lines dbGaP Data
PENN001i-87-2 iPS-87-098-SeV2 Human iPS None reported Female 29 years Caucasian No No
PENN002i-442-1 iPS-442-SeV1 Human iPS None reported Female 24 years Caucasian No No
PENN003i-661-4 661-SeV4 Human iPS None reported Male 40 years African American No No
PENN004i-277-1 iPS-277-SeV1 Human iPS None reported Male 37 years Caucasian No No
PENN005i-35-3 iPS-35-1360-010-SeV3 Human iPS None reported Male 30 years Caucasian No No
PENN006i-149-1 iPS-149-SeV1 Human iPS None reported Female 27 years Caucasian No No
PENN008i-77-5 iPS-77-1638-SeV5 Human iPS None reported Male 28 years Caucasian No No
PENN009i-57-52 iPS-57-1673-SeV52 Human iPS None reported Female 24 years Caucasian No No
PENN010i-486-2 iPS-486-1610-080-SeV2 Human iPS None reported Female 29 years Caucasian No No
PENN011i-719-2 iPS-719-SeV2 Human iPS None reported Female 49 years African American No No
Cell Lines 169 Cell Lines
Items per page 10 20 Show All >>
Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17