WISCi004-A-4 is a modified version of the YZ1 iPS cell line (YZ1 is derived from IMR90 fibroblasts), which has been modified to induce a genetic mutation of the DISC1 exon. This gene disruption segregates with schizophrenia and related psychiatric disorders.

** Upon testing, the current lot of material did not meet WiCell’s standards for quality, and it is therefore unavailable. WiCell is working with the Provider to obtain replacement materials for distribution. To be notified of the status of this cell line please submit your information here.
Cell Line Alias YZ1 DISC1 ex8wm v2.27
Cell Type Human iPS
Disease Mental illness
Diagnosis Information Diagnosis based on a genetic modification of DISC1.
Genetic Alteration/Mutation DISC1 exon 8 wild-type mutation
Genetic Alteration/Mutation Information Induced genetic mutation
Genetic Modification Keyword Engineered
Sex Female  
Age at Collection fetal
Genetically Related Cell Lines  
Reprogramming Method Viral transfection (Lentivirus: Oct4, Klf4, Sox2, cMyc)
Tissue Origin Lung Fibroblast
Provider Brigham and Women`s Hospital - Dr.Tracy Young-Pearse
dbGaP Data  
Eagle-I UID  
hPSCReg ID  
NIH Approval  
Pub Med Abstract  
Related Products

Current Lot Information

Lot Number Culture Platform Lot Description Passage Number Banked By Protocol Product Information & Testing
DB46591 Stem Cell Culture Medium (KOSR/MEF) 112 Provider WiCell Feeder Dependent Protocol PDF