Yes, Matrigel is a Basement Membrane Extract (BME) and equivalent BMEs include Cultrex and Geltrex. We have found the Cultrex can be used interchangeably in our protocols with Matrigel. Use of Geltrex, however would need to be optimized to suit your application. Alternatively, some cultures will work with Vitronectin, Laminin, or other protein matrices, but may need ROCK inhibitors for attachment. We suggest you test any matrix for support prior to your experiments or use a Human PSC qualified product.