Cytogenetics
WiCell Cytogenetics Laboratory specializes in cytogenetic testing of human and mouse embryonic stem cells and induced pluripotent stem cells. For more information please contact the WiCell Cytogenetics Laboratory. (Download a complete testing guidelines table.) 

WiCell Cytogenetics Laboratory Guidelines for cytogenetic testing methods of pluripotent stem cell lines
AssayWhen to Use
  • As a baseline genomic screen
    • At derivation of cell lines
    • At the start of experimental protocols
    • To assess and monitor genomic stability (ex. every 5-10 passages of cell culture)
    • At conclusion of experiments (prior to publication)
    • For cell line banking
  • When publication-quality karyotypes are needed
  • As an adjunct to g-banded karyotyping
    • To define complex rearrangements
    • To identify marker chromosomes
  • When publication-quality spectral karyotypes are needed
  • As a baseline genomic screen
    • To detect submicroscopic (<5Mb) abnormalities
    • To identify amplified or deleted genes of interest
  • In conjunction with g-banded karyotyping
    • To define translocation breakpoints
  • For research of genomic copy number change
    • To identify structural variation within populations or disease cohorts
    • To develop a cell line copy number variant profile
  • To confirm findings and refine breakpoints detected by g-banded karyotyping
  • To confirm findings and localize genomic gains detected by aCGH analysis
  • As a screen for microdeletions/duplications of known targets
  • As a screen for aneuploidies other than X, 8, 12, and 17
  • As a rapid screen for large numbers of clones
  • As a cost-effective tool for monitoring aneuploidy
  • To monitor identity of a cell line
  • To confirm relationship of iPS cells to their parent line
  • To establish an STR profile of a newly derived or reprogrammed cell line
  • To rule out culture cross-contamination
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