Powered by Bioz** This cell line has an unexpected abnormal karyotype. Please see the karyotype report in the “Product Information & Testing” PDF(s) linked below for more information.
This Beta2Microglobulin-targeted cell line is a modified version of Elf1. One allele is negative for B2M, the other expresses an HLA-E single-chain trimer which contains an additional (G4S)3 linker fused to a peptide derived from the signal sequence of HLA-G, a non-polymorphic peptide normally presented by HLA-E that inhibits NK cell-dependent lysis through its binding to CD94/NGK2A.
- Cell Line Alias -/Etrimer
- Unit of Measure (UOM) vial
- Cell Type Modified Human ES
- Sex Female
- Genetic Modification Keyword Isogenic; Immune rejection
- Disease None reported
- Genetic Alteration Mutation B2M
- Pubmed Abstract Gornalusse, German et al. ""HLA-E-expressing pluripotent stem cells escape allogeneic responses and lysis by NK cells"" Nature Biotechnology 35.8 (2016): 265-772.
- Provider University of Washington - Dr. David Russell
- Collections Uncategorized
| Lot Number | Culture Platform | Lot Description | Banked By | Passage Number | Protocol | Product Info URL |
| WB67154 | hESC Medium (KOSR)/MEF and ELF1 Supplements | WiCell | 14 | WiCell Feeder Based (MEF) Pluripotent Stem Cell Protocol and Supplement culture of Elf1 Cells |