Powered by BiozThis cell line is a modified version of the YZ1 iPS cell line (YZ1 is derived from IMR90 fibroblasts), engineered to induce mutation of the DISC1 exon. This gene disruption segregates with schizophrenia and related psychiatric disorders.
**Upon testing, the current lot of material did not meet WiCell`s standards for quality, and it is therefore unavailable. WiCell is working with the Provider to obtain replacement materials for distribution. To be notified of the status of this cell line please submit your information here.
- Cell Line Alias YZ1 DISC1 ex8wm v2.27
- Unit of Measure (UOM) vial
- Cell Type Modified Human iPS
- Sex Female
- Reprogramming Method Viral transfection (Lentivirus: Oct4, Klf4, Sox2, cMyc)
- Tissue Origin Lung Fibroblast
- Genetic Alteration Mutation Information Induced genetic mutation
- Diagnosis Information Diagnosis based on a genetic modification of DISC1.
- Genetic Modification Keyword Isogenic; schizophrenia
- Disease Mental illness
- Genetic Alteration Mutation DISC1 exon 8 wild-type mutation
- Pubmed Abstract Sriknanth P et al "Genomic DISC1 Disruption in hiPSCs Alters Wnt Signaling and Neural Cell Fate." Cell Reports 12.9 (2015): 1414-1429.|Zeng H et al "Specification of region-specific neurons including forebrain glutamatergic neurons from human induced pluripotent stem cells." PLoS ONE 5.7 (2010) e11853.
- hPSCReg ID WISCi004-A-4
- Provider Brigham and Women`s Hospital - Dr.Tracy Young-Pearse
- Collections Uncategorized
| Lot Number | Culture Platform | Lot Description | Banked By | Passage Number | Protocol | Product Info URL |
| DB46591 | Stem Cell Culture Medium (KOSR/MEF) | Provider | 112 | WiCell Feeder Based (MEF) Pluripotent Stem Cell Protocol |