Embryonal Carcinoma Human ES Human iPS Modified Human ES Modified Human iPS Neural Stem Cell

16p11.2 disorders ABCA1 heterozygous Abetalipoproteinemia Alexander disease (Type II) Amyotrophic lateral sclerosis Arrhythmogenic Right Ventricular Cardiomyopathy Associated Pulmonary Arterial Hypertension status post and patent ductus arteriosus Associated Pulmonary Arterial Hypertension with Drugs and Toxins-Associated history Associated Pulmonary Arterial Hypertension with Eisenmenger's Syndrome Associated Pulmonary Arterial Hypertension with Lupus and pulmonary fibrosis Associated Pulmonary Arterial Hypertension with pulmonary veno-occlusive disease Associated Pulmonary Arterial Hypertension with ventricular septal defect and Eisenmenger's Syndrome Atrial Fibrillation Atrial Fibrillation|Coronary artery disease Atrial Fibrillation|Coronary artery disease|Interstitial Lung disease Atrial Fibrillation|Right Ventricular Outflow Tract Premature Ventricular Contractions Atrial Tachycardia Beta Thalassemia Carrier of Limb-Girdle Muscular Dystrophy Carrier of Spinal Muscular Atrophy (Type II) Carrier of X-linked Dystonia Parkinsonism Charcot-Marie-Tooth disease type 2A Choroideremia Chronic Myeloid Leukemia Congenital Heart Block Coronary artery disease Coronary artery disease|Myocardial infarction Danon disease Dilated Cardiomyopathy Down syndrome, Trisomy 21 Duchenne Muscular Dystrophy Familial Alzheimer`s disease Familial Pulmonary Arterial Hypertension Familial Pulmonary Arterial Hypertension with Drugs and Toxins-Associated history Fragile X premutation Fragile X syndrome Fragile X syndrome|Autism Homozygous Familial Hypercholesterolemia Hyperalphalipoproteinemia Hypertrophic Cardiomyopathy Idiopathic Pulmonary Arterial Hypertension Inappropriate Sinus Tachycardia Klinefelter syndrome Left ventricular hypertrophy Left ventricular non-compaction Limb-Girdle Muscular Dystrophy, LGMD2B Mental illness Mild Left Ventricular Hypertrophy|Resolved Systolic Anterior Motion (of the mitral valve) Neuronal ceroid lipofuscinosis (Type II) None reported Nonseminomatous Germ Cell Tumor PACS1 (Schuurs-Hoeijmakers) syndrome PACS2 Syndrome Patau Syndrome Pulmonary Atresia Rett syndrome Right Ventricular Outflow Tract Premature Ventricular Contractions Severe Combined Immunodeficiency Sickle cell anemia SS Spinal Muscular Atrophy (Type I) Spinal Muscular Atrophy (Type II) Sporadic Alzheimer's disease Tangier disease Timothy Syndrome Turner Syndrome Ventricular tachycardia Ventricular tachycardia|Atrial Fibrillation|Long QT syndrome Ventricular tachycardia|Congenital Heart Block Ventricular tachycardia|Long QT syndrome Ventricular tachycardia|Long QT syndrome 2 Ventricular tachycardia|Small Atrial Septal Defect X-linked Dystonia Parkinsonism

1 Months 1 Years 10 Months 10 Years 100 Years 11 Years 12 Years 13 Years 14 Years 15 Years 16 Years 18 Years 19 Years 2 Years 20 Years 21 Years 22 Years 23 Years 24 Years 25 Years 26 Years 27 Years 28 Years 29 Years 3 Years 30 Years 31 Years 32 Years 33 Years 34 Years 35 Years 36 Years 37 Years 38 Years 39 Years 40 Years 41 Years 42 Years 43 Years 44 Years 45 Years 46 Years 47 Years 48 Years 49 Years 5 Years 50 Years 51 Years 51-60 Years 52 Years 53 Years 54 Years 55 Years 56 Years 57 Years 58 Years 59 Years 6 Years 60 Years 61 Years 61-70 Years 62 Years 63 Years 64 Years 65 Years 66 Years 67 Years 68 Years 69 Years 7 Months 7 Years 70 Years 71 Years 71-80 Years 72 Years 73 Years 74 Years 75 Years 76 Years 77 Years 78 Years 79 Years 8 Years 80 Years 81 Years 81-90 Years 82 Years 83 Years 84 Years 85 Years 86 Years 87 Years 88 Years 89 Years 9 Years 90 Years 91 Years 92 Years 93 Years 94 Years 95 Years Adult Neonatal

Female Male

47,XX,+21 (Trisomy 21) 47,XXY (Extra X chromosome) 47,XY,+21 (Trisomy 21) ABC1(K531N)het ABC1(K531N)het; ABC1(S2046R)het ABCA1 ABCA1(R1210stop)het; ABCA1(intron 32,G[-25]C)het ADA ALK1 APP (duplication) APPV717l mutation B2M BMPR2(R491W) CACNA1C CCR5 DISC1 exon 8 wild-type mutation DYSF (heterozygous 1 mutation) DYSF (heterozygous 2 mutations) ETV2 FMR1 FMR1 Knockout FMR1-FLAG GFAP GFAP Corrected HBB HBB(E6V) HBB(E6V) Corrected KCTD13 LDLR(del exon3-6)homo LDLR(del exon4-6)het MECP2 MFN2 MTP(R46G) MYH11 PACS1 PACS2 SMN1 SOD1 > D90A SOD1 > D90A Corrected SR-BI TAF1 Variant TAF1 variant (hemizygous carrier) TAF1 Variant (heterozygous carrier) TAF1 variant (homozygous carrier) TAF1 Variant Corrected TPP1

African American African American > Nigerian African American|Asian African American|Latino Arab Asian Asian > Chinese Asian > Chinese|Caucasian Asian > Filipino Asian > Indian Asian > Irani Asian > Iraqi Asian > Japanese Asian > Japanese|Caucasian Asian > Japanese|Caucasian > European Asian|Caucasian Asian|Latino Caucasian Caucasian > European Caucasian > European Asian > Indian Caucasian > Nordic Caucasian|Latino Caucasian|Latino > North American Caucasian|Latino > North American|Native American Caucasian|Native American Latino Latino > North American Latino > South American Latino|Native American None Reported Pacific Islander Unknown

GFP (constitutive) Isogenic; Alexander disease (Type II) Isogenic; Amyotrophic lateral sclerosis Isogenic; Autism Isogenic; Down syndrome, Trisomy 21 Isogenic; Fragile X syndrome Isogenic; HIV Isogenic; Immune rejection Isogenic; Neuronal ceroid lipofuscinosis (Type II) Isogenic; Rett syndrome Isogenic; schizophrenia Isogenic; Sickle cell Isogenic; Twin Isogenic; X-linked Dystonia Parkinsonism N/A Reporter; Cardiac Reporter; Constitutive Reporter; Endothelial Reporter; Endothelial|Reporter; Hematopoetic Reporter; Neural Reporter; Self-renewal - Pluripotency Reporter; Vascular Reporter; Vascular - Smooth Muscle Cells

"Boston University and Boston Medical Center's Center for Regenerative Medicine (CReM) - Dr. Steinberg, Dr. Mostoslavsky, Dr. Murphy" "University of California - San Diego, Dr. Kelly Frazer" "University of California - San Diego, Dr. Larry Goldstein" "University of California, San Diego - Dr. Karl Willert" "University of Luebeck - Dr. Christine Klein, Dr. Karen Gruetz, Dr. Philip Seibler" Allen Institute - Dr. Boaz Levi Biotrophix Pty. - Dr. Martin Pera Boston Children's Hospital - Dr. George Daley Bresagen/Vertex Brigham and Women`s Hospital - Dr.Tracy Young-Pearse Brown University - Dr. Eric Morrow Buck Institute Cellartis/Takara Choroideremia Research Foundation ESI/BioTime Fred Hutchinson Cancer Research Center - Dr. Beverly Torok-Storb Harvard Stem Cell Institute - Dr. Chad Cowan Jain Foundation Life Technologies Massachusetts General Hospital Medical College of Wisconsin - Dr. Ulrich Broeckel Morgridge Institute for Research - Dr. James Thomson PACS1 Foundation PACS2 Research Foundation Stanford University - Dr. Marlene Rabinovitch Stanford University - Dr. Thomas Quertermous Technion The Johns Hopkins University - Dr. Elias Zambidis The Johns Hopkins University - Dr. Lewis Becker The Rockefeller University - Dr. Ali Brivanlou The Scripps Research Institute - Dr. Eric Topol University of California - San Francisco University of Minnesota - Dr. Michael Kyba University of Pennsylvania - Dr. Daniel Rader University of Washington - Dr. Carol Ware University of Washington - Dr. David Russell University of Wisconsin - Dr. Anita Bhattacharyya University of Wisconsin - Dr. Anita Bhattacharyya and Dr. Xinyu Zhao University of Wisconsin - Dr. Ei Terasawa University of Wisconsin - Dr. Igor Slukvin University of Wisconsin - Dr. James Thomson University of Wisconsin - Dr. John Svaren University of Wisconsin - Dr. Qiang Chang University of Wisconsin - Dr. Su-Chun Zhang University of Wisconsin - Dr. Timothy Kamp WiCell