Powered by BiozThis cell line is a modified version of WA09 (H9), engineered by knocking-in a homozygous mutation at the TPP1 locus to produce a common variant responsible for Neuronal ceroid lipofuscinosis-2 (CLN2) disease. Support from the Sandra Nusinoff Lerhman and Stephen Lehrman Family Fund was essential in the development of this cell line.
- Unit of Measure (UOM) vial
- Cell Type Modified Human ES
- Sex Female
- Genetic Alteration Mutation Information SA mutation homozygous c.509-1 G>C
- Genetic Modification Keyword Isogenic; Neuronal ceroid lipofuscinosis (Type II)
- Disease Neuronal ceroid lipofuscinosis (Type II)
- Genetic Alteration Mutation TPP1
- Pubmed Abstract Li Ma et al "Generation of Pathogenic TPP1 Mutations in Human Stem Cells as a Model for CLN2 Disease". bioRxiv (2021). doi: https://doi.org/10.1101/2021.01.05.425495.
- hPSCReg ID WAe009-A-53
- Provider Brown University - Dr. Eric Morrow
- Collections Uncategorized
| Lot Number | Culture Platform | Lot Description | Banked By | Passage Number | Protocol | Product Info URL |
| DB67601 | TeSR-E8/Matrigel | Provider | 38 | WiCell Feeder Independent Pluripotent Stem Cell Protocol |