Powered by BiozA modified, isogenic control cell line, GFAP-R88R, is available from WiCell.
- Cell Line Alias C88
- Unit of Measure (UOM) vial
- Cell Type Human iPS
- Sex Male
- Age at Collection 5 Years
- Reprogramming Method Non-Integrating (Episomal Plasmid: Oct4, Klf4, Sox2, cMyc)
- Tissue Origin Fibroblasts
- Genetic Alteration Mutation Information C->T transition results in mutation at amino acid residue 88.
- Diagnosis Information Diagnosis of Alexander disease was physician reported.
- Disease Alexander disease (Type II)
- Genetic Alteration Mutation GFAP
- Pubmed Abstract Jones, Jeffrey R et al. "Mutations in GFAP Disrupt the Distribution and Function of Organelles in Human Astrocytes" Cell Reports 25.4 (2018): 947-958.
- hPSCReg ID WISCi015-A
- Provider University of Wisconsin - Dr. Su-Chun Zhang
- Collections Alexander disease Collection
| Lot Number | Culture Platform | Lot Description | Banked By | Passage Number | Protocol | Product Info URL |
| WB67454 | mTeSR1/Matrigel | WiCell | 19 | WiCell Feeder Independent Pluripotent Stem Cell Protocol |