Amyotrophic lateral sclerosis Collection

Amyotrophic lateral sclerosis (ALS), also called Lou Gehrig’s disease, is the most common motor neuron disease.  ALS is progressive and fatal and there is currently no effective treatment. Most cases of ALS are sporadic, but 5-10% of cases are associated with genetic mutations, among which 20% are caused by mutations in the SOD1 gene.  Affected individuals lose voluntary muscle control compromising their ability to speak, move, eat and breathe.

 This collection, deposited by Dr. Su-Chun Zhang from the University of Wisconsin-Madison, consists of iPSC lines reprogrammed from primary fibroblasts from one patient with ALS, caused by a SOD1 genetic mutation. The cell lines available include an affected ALS cell line and a genetically corrected isogenic control cell line.   

The publication describing this collection of iPSC lines can be found here.

Cell Lines 2 Cell Lines
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Cell Line Cell Line Alias Cell Type Disease Genetic Alteration/Mutation Sex Age at Collection Ethnicity Genetically Related Cell Lines dbGaP Data
WC034i-SOD1-D90A   Human iPS Amyotrophic lateral sclerosis   SOD1 > D90A  Female 50 Years Caucasian  No No
WC035i-SOD1-D90D   Modified Human iPS Cells None reported  SOD1 > D90A Corrected  Female 50 Years Caucasian  No No
Cell Lines 2 Cell Lines
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