Down syndrome (Bhattacharyya) Collection
Down syndrome is one of the most common chromosome abnormalities and most frequent genetic cause of intellectual disability in humans and is caused by trisomy of human chromosome 21 (Ts21). This iPSC collection, deposited by Dr. Anita Bhattacharyya from the University of Wisconsin-Madison, is derived from fibroblasts of individuals with Down syndrome. The collection includes iPSC lines derived from donors mosaic for Ts21, which allows both Ts21 and isogenic diploid control iPSCs to be derived from the same individual.
Publications describing cell lines included in this collection of iPSCs may be found here and here.
Cell Line 
|
Cell Line Alias
|
Cell Type
|
Disease | Genetic Alteration/Mutation |
Sex
|
Age at Collection
|
Ethnicity | Genetically Related Cell Lines |
dbGaP Data
|
|---|---|---|---|---|---|---|---|---|---|
| UWWC1-2DS3 | 2DS3 | Human iPS | Down syndrome, Trisomy 21 | 47,XY,+21 (Trisomy 21) | Male | 1 Months | No | No | |
| UWWC1-DS1 | DS1 | Human iPS | Down syndrome, Trisomy 21 | 47,XY,+21 (Trisomy 21) | Male | 1 Years | No | No | |
| UWWC1-DS2U | DS2U | Modified Human iPS | None reported | Male | 1 Years | No | No | ||
| UWWC1-DS4 | DS4 | Human iPS | Down syndrome, Trisomy 21 | 47,XY,+21 (Trisomy 21) | Male | 1 Years | No | No | |
| WC-24-02-DS-A | Human iPS | None reported | Female | 25 Years | Caucasian | No | No | ||
| WC-24-02-DS-B | Human iPS | None reported | Female | 25 Years | Caucasian | No | No | ||
| WC-24-02-DS-C | Human iPS | None reported | Female | 25 Years | Caucasian | No | No | ||
| WC-24-02-DS-M | Human iPS | Down syndrome, Trisomy 21 | 47,XX,+21 (Trisomy 21) | Female | 25 Years | Caucasian | No | No | |
| WC-24-02-DS-O | Human iPS | Down syndrome, Trisomy 21 | 47,XX,+21 (Trisomy 21) | Female | 25 Years | Caucasian | No | No | |
| WC-24-02-DS-P | Human iPS | Down syndrome, Trisomy 21 | 47,XX,+21 (Trisomy 21) | Female | 25 Years | Caucasian | No | No |
