Down syndrome (Bhattacharyya) Collection

Down syndrome is one of the most common chromosome abnormalities and most frequent genetic cause of intellectual disability in humans and is caused by trisomy of human chromosome 21 (Ts21). This iPSC collection, deposited by Dr. Anita Bhattacharyya from the University of Wisconsin-Madison, is derived from fibroblasts of individuals with Down syndrome. The collection includes iPSC lines derived from donors mosaic for Ts21, which allows both Ts21 and isogenic diploid control iPSCs to be derived from the same individual. 

Publications describing cell lines included in this collection of iPSCs may be found here and here.

Cell Lines 10 Cell Lines
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Cell Line Cell Line Alias Cell Type Disease Genetic Alteration/Mutation Sex Age at Collection Ethnicity Genetically Related Cell Lines dbGaP Data
UWWC1-2DS3 2DS3 Human iPS Down syndrome, Trisomy 21  47,XY,+21 (Trisomy 21)  Male 1 Months   No No
UWWC1-DS1 DS1 Human iPS Down syndrome, Trisomy 21  47,XY,+21 (Trisomy 21)  Male 1 Years   No No
UWWC1-DS2U DS2U Modified Human iPS None reported    Male 1 Years   No No
UWWC1-DS4 DS4 Human iPS Down syndrome, Trisomy 21  47,XY,+21 (Trisomy 21)  Male 1 Years   No No
WC-24-02-DS-A   Human iPS None reported    Female 25 Years Caucasian  No No
WC-24-02-DS-B   Human iPS None reported    Female 25 Years Caucasian  No No
WC-24-02-DS-C   Human iPS None reported    Female 25 Years Caucasian  No No
WC-24-02-DS-M   Human iPS Down syndrome, Trisomy 21  47,XX,+21 (Trisomy 21)  Female 25 Years Caucasian  No No
WC-24-02-DS-O   Human iPS Down syndrome, Trisomy 21  47,XX,+21 (Trisomy 21)  Female 25 Years Caucasian  No No
WC-24-02-DS-P   Human iPS Down syndrome, Trisomy 21  47,XX,+21 (Trisomy 21)  Female 25 Years Caucasian  No No
Cell Lines 10 Cell Lines
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