This collection, from Dr. Daniel Rader (University of Pennsylvania), was generated with the goal of creating a library of iPS cell lines and iPS-derived hepatocytes of differing genotype for use in metabolic profiling and interrogating lipid phenotypes.  The iPS cell lines from these studies are included within this collection. 

This collection contains 171 cell lines.  Individuals giving rise to iPSC lines were from the “GENE Study”, and includes individuals with Homozygous Familial Hypercholesterolemia, Tangier Disease, Abetalipoproteinemia, and Hyperalphalipoproteinemia as well as individuals with no reported diagnoses.  The age of donors range from 20-66 and various ethnicities. 

Additional information regarding relationships can be found here.

Please also see Lipid Serum Measurements and Blood Type for these cell lines.

About the Next Generation Genetic Association Studies (Next Gen) Program         

These cell lines were created as Next Generation Genetic Association Studies (Next Gen) Program, which was a five-year, $80 million program to investigate functional genetic variation in humans by assessing cellular profiles that are surrogates for disease phenotypes. To achieve this, researchers from multiple institutions across the U.S. were awarded grants to derive iPS cell lines from more than 1,500 individuals representing various conditions as well as healthy controls for use in functional genomic (‘disease in a dish’) research. This extensive panel includes a diverse set of age, gender and ethnic backgrounds, and therefore will be an invaluable tool for evaluations across demographics. Further enhancing the utility of these cell lines are data sets such as phenotyping, GWAS, genome sequencing, gene expression and -omics analyses (e.g., lipidomic, proteomic, methylomic) that will be made available with the cell lines.