Progenitor Cell Biology Consortium (PCBC) Collection

The Progenitor Cell Biology Consortium (PCBC) of the National Heart, Lung, and Blood Institute (NHLBI) was founded to study iPSCs reprogramming and differentiation, and develop strategies to address the challenges with transplantation of these cells. 

It is unclear whether all methodologies produce iPSCs with a similar quality and stability. Limited direct comparisons of iPSCs generated from independent laboratories have been done due to the extensive resources required. It was for this reason that PCBC performed comprehensive experimental and genomic analyses of iPSC and hESC lines from different laboratories derived using a variety of reprogramming methods.  Culture systems for the cell lines were harmonized, and comprehensive genomic and experimental analysis were performed on the materials.  All resulting data is publicly available through Synapse.  

Materials generated directly from these highly characterized lines are available from WiCell.  

These characterized iPSC and hESC lines are available through WiCell.  The publication describing this cohort can be found here.

Cell Lines 15 Cell Lines
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Cell Line Cell Line Alias Cell Type Disease Genetic Alteration/Mutation Sex Age at Collection Ethnicity Genetically Related Cell Lines dbGaP Data
029 iPS clone 4-PCBC SC13-049; PCBC16hsi2013040201 Human iPS None reported    Male  Adult Unknown  N/A No
CBiPS-6.13-PCBC SC11-010; PCBC03hsi2011080403 Human iPS None reported    Female  Neonatal Unknown  N/A No
CBiPS-E12C1-PCBC SC11-012; PCBC03hsi2011080405 Human iPS None reported    Female  Neonatal Unknown  N/A No
CBiPS-E17C6-PCBC SC11-013; PCBC03hsi2011080406 Human iPS None reported    Female  Neonatal Unknown  N/A No
CBiPS-LZ6-1-PCBC SC14-069; PCBC03hsi2014031101; 4F CB-iPSC-MSC Human iPS None reported    Female  Neonatal Unknown  N/A No
CBiPS-LZ6-2-PCBC SC14-070; PCBC03hsi2014031102; 4F CB-iPSC-MSC Human iPS None reported    Female  Neonatal Unknown  N/A No
IISH1i-BM1-PCBC SC13-043; PCBC02hsi2012090602 Human iPS None reported    Female     No No
IISH2i-BM9-PCBC SC13-044; PCBC02hsi2012090601; BM9 Human iPS None reported    Female     No No
IISH3i-CB6-PCBC SC13?045; PCBC02hsi2012090603 Human iPS None reported    Female     No No
iPS DF19-9-7T-PCBC SC11-016; PCBC02hsi2011100701 Human iPS None reported    Male     No No
Cell Lines 15 Cell Lines
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