Amyotrophic lateral sclerosis Collection

Amyotrophic lateral sclerosis Collection

Amyotrophic lateral sclerosis (ALS), also called Lou Gehrig’s disease, is the most common motor neuron disease. ALS is progressive and fatal and there is currently no effective treatment. Most cases of ALS are sporadic, but 5-10% of cases are associated with genetic mutations, among which 20% are caused by mutations in the SOD1 gene. Affected individuals lose voluntary muscle control compromising their ability to speak, move, eat and breathe.

This collection, deposited by Dr. Su-Chun Zhang from the University of Wisconsin-Madison, consists of iPSC lines reprogrammed from primary fibroblasts from one patient with ALS, caused by a SOD1 genetic mutation. The cell lines available include an affected ALS cell line and a genetically corrected isogenic control cell line.

The publication describing this collection of iPSC lines can be found here.

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Showing 1 – 2 of 2 Cell Lines 2 Cell Lines Showing the single result No results found
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Cell Line
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Cell Type
Disease
Genetic Alteration/Mutation
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Genetically Related Cell Lines
dbGaP Data
Human iPS
Amyotrophic lateral sclerosis
Female
50 Years
Caucasian
No
No
Modified Human iPS
None reported
Female
50 Years
Caucasian
No
No

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