NHLBI Next Gen - Lipid Conditions (Dr. Daniel Rader, University of Pennsylvania)

NHLBI Next Gen - Lipid Conditions (Dr. Daniel Rader, University of Pennsylvania)

About Rader Lab’s Next Gen Cell Lines

This collection, from Dr. Daniel Rader (University of Pennsylvania), was generated with the goal of creating a library of iPS cell lines and iPS-derived hepatocytes of differing genotype for use in metabolic profiling and interrogating lipid phenotypes. The iPS cell lines from these studies are included within this collection.

This collection contains 171 cell lines. Individuals giving rise to iPSC lines were from the “GENE Study”, and includes individuals with Homozygous Familial Hypercholesterolemia, Tangier Disease, Abetalipoproteinemia, and Hyperalphalipoproteinemia as well as individuals with no reported diagnoses. The age of donors range from 20-66 and various ethnicities.

Additional information regarding relationships can be found here.

Please also see Lipid Serum Measurements and Blood Type for these cell lines.

About the Next Generation Genetic Association Studies (Next Gen) Program

These cell lines were created as Next Generation Genetic Association Studies (Next Gen) Program, which was a five-year, $80 million program to investigate functional genetic variation in humans by assessing cellular profiles that are surrogates for disease phenotypes. To achieve this, researchers from multiple institutions across the U.S. were awarded grants to derive iPS cell lines from more than 1,500 individuals representing various conditions as well as healthy controls for use in functional genomic (‘disease in a dish’) research. This extensive panel includes a diverse set of age, gender and ethnic backgrounds, and therefore will be an invaluable tool for evaluations across demographics. Further enhancing the utility of these cell lines are data sets such as phenotyping, GWAS, genome sequencing, gene expression and -omics analyses (e.g., lipidomic, proteomic, methylomic) that will be made available with the cell lines.

Showing 1–16 of 171 results

Showing 1 – 10 of 171 Cell Lines 171 Cell Lines Showing the single result No results found
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Cell Line
Cell Line Alias
Cell Type
Disease
Genetic Alteration/Mutation
Sex
Age at Collection
Ethnicity
Genetically Related Cell Lines
dbGaP Data
iPS-87-098-SeV2
Human iPS
None reported
Female
29 Years
Caucasian
No
No
iPS-442-SeV1
Human iPS
None reported
Female
24 Years
Caucasian
No
No
661-SeV4
Human iPS
None reported
Male
40 Years
African American
No
No
iPS-277-SeV1
Human iPS
None reported
Male
37 Years
Caucasian
No
No
iPS-35-1360-010-SeV3
Human iPS
None reported
Male
30 Years
Caucasian
No
No
iPS-149-SeV1
Human iPS
None reported
Female
27 Years
Caucasian
No
No
765-SeV3
Human iPS
None reported
Female
23 Years
African American
No
No
iPS-77-1638-SeV5
Human iPS
None reported
Male
28 Years
Caucasian
No
No
iPS-57-1673-SeV52
Human iPS
None reported
Female
24 Years
Caucasian
No
No
iPS-486-1610-080-SeV2
Human iPS
None reported
Female
29 Years
Caucasian
No
No
1218

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