Parkinson’s LRRK2 iPSC Cell Line Collection

Developed in the Schuele Laboratory at Stanford University School of Medicine, the LRRK2 (ESCAPE) collection contains human induced pluripotent stem cell (iPSC) lines focused on pathogenic LRRK2 gene variants. The series includes homozygous and heterozygous LRRK2 p.G2019S mutants, isogenic derivatives generated by Zinc Finger Nuclease (ZFN) editing (biallelic correction, knockout, and unedited controls), healthy controls, and a unique double-mutant line combining LRRK2 p.G2019S with a PARKIN (PRKN) exon 5 copy-number variation. These lines have been widely adopted and cited in multiple peer-reviewed studies and provide a robust, validated platform for modeling LRRK2-associated PD and evaluating new therapeutic approaches.