Spinal Muscular Atrophy Collection
Spinal muscular atrophy (SMA) Type I, also called Werdnig-Hoffmann disease, is a neuromuscular disorder characterized by the degeneration of spinal cord motor neurons, caused by a loss or mutation of the SMN1 gene. Affected individuals develop severe weakness and atrophy of the muscles used in crawling, walking, swallowing and breathing.
This iPSC collection, deposited by Dr. Su-Chun Zhang from the University of Wisconsin-Madison, serves as a model for the SMN1 gene mutation. The collection consists of iPSC lines reprogrammed from fibroblasts of three affected type-1 SMA donors with homozygous deletions in the SMN1 gene, and two carriers with heterozygous deletions in the SMN1 gene that are clinically unaffected. Cell lines available include those from an affected donor and carrier donors within the same family. Additional information regarding relationships can be found here.
The publication describing this collection of iPSC lines may be found here.
Showing all 5 results
Cell Line | Cell Line Alias | Cell Type | Disease | Genetic Alteration/Mutation | Sex | Age at Collection | Ethnicity | Genetically Related Cell Lines | dbGaP Data |
---|---|---|---|---|---|---|---|---|---|
SMA-1 | Human iPS | Spinal Muscular Atrophy (Type II) | 3 copies of SMN2 gene with homozygous deletion of exons 7 and 8 in SMN1 gene | Male | 3 Years | Caucasian | Yes | No | |
Contl-2 | Human iPS | Carrier of Spinal Muscular Atrophy (Type II) | 5 copies of SMN2 gene with heterozygous deletion of exons 7 and 8 in the SMN1 gene | Female | Caucasian | Yes | No | ||
Contl-3 | Human iPS | Carrier of Spinal Muscular Atrophy (Type II) | 1 copy of SMN2 gene | Male | Caucasian | Yes | No | ||
SMA-2 | Human iPS | Spinal Muscular Atrophy (Type I) | 3 copies of SMN2 gene with homozygous deletion of exons 7 and 8 in SMN1 gene | Male | 2 Years | Caucasian | No | No | |
SMA-3 | Human iPS | Spinal Muscular Atrophy (Type I) | 2 copies of the SMN2 gene and is homozygous for deletion of exons 7 and 8 of the SMN1 gene | Male | 7 Months | Caucasian | No | No |