Powered by BiozA modified, isogenic control cell line, GFAP-R416R, is available from WiCell.
- Cell Line Alias W416
- Unit of Measure (UOM) vial
- Cell Type Human iPS
- Sex Male
- Age at Collection 8 Years
- Reprogramming Method Non-Integrating (Episomal Plasmid: Oct4, Klf4, Sox2, cMyc)
- Tissue Origin Fibroblasts
- Genetic Alteration Mutation Information C->T transition results in mutation at amino acid residue 416.
- Diagnosis Information Diagnosis of Alexander disease was physician reported.
- Disease Alexander disease (Type II)
- Genetic Alteration Mutation GFAP
- Pubmed Abstract Jones, Jeffrey R et al. "Mutations in GFAP Disrupt the Distribution and Function of Organelles in Human Astrocytes" Cell Reports 25.4 (2018): 947-958.
- hPSCReg ID WISCi016-A
- Provider University of Wisconsin - Dr. Su-Chun Zhang
- Collections Alexander disease Collection
| Lot Number | Culture Platform | Lot Description | Banked By | Passage Number | Protocol | Product Information & Testing |
| WB67486 | mTeSR1/Matrigel | WiCell | 18 | WiCell Feeder Independent Pluripotent Stem Cell Protocol |