** This cell line has an unexpected abnormal karyotype. Please see the karyotype report in the “Product Information & Testing” PDF(s) linked below for more information.

This cell line, which serves as a model for Down Syndrome (Trisomy 21), was created by reprogramming a Down Syndrome (Trisomy 21) human fibroblast line. This cell line contains (IRES)-TKNEO-polyadenylation site cassette in exon 3 of the Amyloid Precursor Protein (APP) gene on chromosome 21, in one allele, for positive-negative selection with thymidine kinase and neomycin. Additional isogenic disomic cell lines (hIPSC-Di21-c2-4-3 and hIPSC-Di21-c2-4-4) are available from WiCell.