Powered by Bioz** This cell line has an unexpected abnormal karyotype. Please see the karyotype report in the “Product Information & Testing” PDF(s) linked below for more information.
This cell line, which serves as a model for Down Syndrome (Trisomy 21), was created by reprogramming a Down Syndrome (Trisomy 21) human fibroblast line. This cell line contains (IRES)-TKNEO-polyadenylation site cassette in exon 3 of the Amyloid Precursor Protein (APP) gene on chromosome 21, in one allele, for positive-negative selection with thymidine kinase and neomycin. Additional isogenic disomic cell lines (hIPSC-Di21-c2-4-3 and hIPSC-Di21-c2-4-4) are available from WiCell.
- Cell Line Alias Tri C2-4
- Unit of Measure (UOM) vial
- Cell Type Human iPS
- Sex Female
- Age at Collection 1 Years
- Reprogramming Method Viral transfection (Lentivirus: Oct4, Sox2, Nanog, Lin28)
- Tissue Origin Skin Fibroblast (AG06872)
- Disease Down syndrome, Trisomy 21
- Ethnicity Caucasian
- Genetic Alteration Mutation 47,XX,+21 (Trisomy 21)
- Pubmed Abstract Li, Li B. et al. ''Trisomy Correction in Down Syndrome Induced Pluripotent Stem Cells'' Cell Stem Cell 11.5 (2012): 615-619.
- Provider University of Washington - Dr. David Russell
- Collections Down syndrome (Russell) Collection
| Lot Number | Culture Platform | Lot Description | Banked By | Passage Number | Protocol | Product Information & Testing |
| WB68517 | mTeSR1/Matrigel | WiCell | 31 | WiCell Feeder Independent Pluripotent Stem Cell Protocol |
| Lot Number | Culture Platform | Lot Description | Banked By | Protocol | Product Information & Testing |
| WB67229 | mTeSR1/Matrigel | WiCell | WiCell Feeder Independent Pluripotent Stem Cell Protocol |