Powered by Bioz** This cell line contains an expected karyotypic abnormality consistent with the phenotype indicated in the “”disease”” field below. Please see the karyotype report in the Product Information & Testing PDF(s) linked below for more information.
This cell line, derived from an individual mosaic for trisomy 21, is a trisomy 21 clone. An additional trisomy 21 clone (UWWC1-DS4) and unmodified isogenic diploid control cell line, UWWC1-DS2U, are available from WiCell.
- Cell Line Alias DS1
- Unit of Measure (UOM) Vial
- Cell Type Human iPS
- Sex Male
- Age at Collection 1 Years
- Reprogramming Method Viral transfection (Lentivirus: Oct4, Klf4, Sox2, cMyc)
- Disease Down syndrome, Trisomy 21
- Genetic Alteration Mutation 47,XY,+21 (Trisomy 21)
- Pubmed Abstract Weick, JP et al. "Deficits in Human Trisomy 21 iPSCs and Neurons" PNAS 110.24 (2013): 9962-7
- hPSCReg ID WISCi005-A
- Provider University of Wisconsin - Dr. Anita Bhattacharyya
- Collections Down syndrome (Bhattacharyya) Collection
| Lot Number | Culture Platform | Lot Description | Banked By | Passage Number | Protocol | Product Info URL |
| WB68233 | mTeSR1/Cultrex | WiCell | 30 | WiCell Feeder Independent Pluripotent Stem Cell Protocol |
| Lot Number | Culture Platform | Lot Description | Banked By | Protocol | Product Info URL |
| WB21343 | mTeSR1/Matrigel | WiCell | WiCell Feeder Independent Pluripotent Stem Cell Protocol |