Powered by Bioz** This cell line contains an expected karyotypic abnormality consistent with the phenotype indicated in the “disease” field below. Please see the karyotype report in the “Product Information & Testing” PDF(s) linked below for more information.
This cell line, derived from an individual mosaic for trisomy 21, is a trisomy 21 clone. Additional trisomy 21 clones (WC-24-02-DS-O and WC-24-02-DS-P) and unmodified isogenic diploid control cell lines, WC-24-02-DS-A, WC-24-02-DS-B and WC-24-02-DS-C, are available from WiCell.
- Unit of Measure (UOM) vial
- Cell Type Human iPS
- Sex Female
- Age at Collection 25 Years
- Reprogramming Method Non-Integrating (Episomal Plasmid: Oct4, Klf4, Sox2, cMyc)
- Tissue Origin Skin
- Disease Down syndrome, Trisomy 21
- Ethnicity Caucasian
- Genetic Alteration Mutation 47,XX,+21 (Trisomy 21)
- Pubmed Abstract Giffin-Rao, Y et al. "Altered Patterning of Interneuron Progenitors in Down Syndrome." BioRxiv (2020). doi.org/10.1101/2020.02.18.951756
- hPSCReg ID WISCi018-D
- Provider University of Wisconsin - Dr. Anita Bhattacharyya
- Collections Down syndrome (Bhattacharyya) Collection
| Lot Number | Culture Platform | Lot Description | Banked By | Passage Number | Protocol | Product Information & Testing |
| WB68400 | mTeSR1/Matrigel | WiCell | 16 | WiCell Feeder Independent Pluripotent Stem Cell Protocol |
| Lot Number | Culture Platform | Lot Description | Banked By | Protocol | Product Information & Testing |
| WB18754 | mTeSR1/Matrigel | WiCell | WiCell Feeder Independent Pluripotent Stem Cell Protocol | ||
| WB67887 | mTeSR Plus/Matrigel | WiCell | WiCell Feeder Independent Pluripotent Stem Cell Protocol |