Powered by BiozThis iPSC line is derived from an affected 18-year-old male TSC patient with a heterozygous C>G point mutation at bp 972. This line serves as a disease model for Tuberous Sclerosis Complex. Isogenic cell lines WC-52-TSC2Corr and WC-52-TSC2Null, as well as engineered counterparts IMR90-TSC2Het and IMR90-TSC2Null are available from WiCell.
- Cell Line Alias WC-52-01A-TG-1, TSC2+/-
- Unit of Measure (UOM) vial
- Cell Type Human iPS
- Sex Male
- Age at Collection 18 years
- Reprogramming Method Non-Integrating (Sendai: Oct4, Klf4, Sox2, cMyc)
- Tissue Origin Skin Fibroblast
- Genetic Alteration Mutation Information 972C/C972G
- Disease Tuberous Sclerosis Complex
- Genetic Alteration Mutation TSC2 (heterozygous)
- Pubmed Abstract Catlett, Timothy S et al. ``RHOA signaling defects result in impaired axon guidance in iPSC-derived neurons from patients with tuberous sclerosis complex.`` Nature communications 12.1 (2021), doi:10.1038/s41467-021-22770-4.
- hPSCReg ID WISCi019-A
- Provider University of Wisconsin - Dr. Timothy Gomez
- Collections Tuberous Sclerosis Complex Collection
| Lot Number | Culture Platform | Lot Description | Banked By | Passage Number | Protocol | Product Information & Testing |
| WB33850 | mTeSR1/Matrigel | Label on vial displays WC-52-01A-TG-1 | WiCell | 13 | WiCell Feeder Independent Pluripotent Stem Cell Protocol |