**Upon testing, the current lot of material did not meet WiCell’s standards for quality, and it is therefore unavailable. WiCell is working with the Provider to obtain replacement materials for distribution. To be notified of the status of this cell line please submit your information here.
- Cell Line Alias APP1.1
- Unit of Measure (UOM) vial
- Cell Type Human iPS
- Sex Male
- Age at Collection 51 Years
- Ethnicity Information Self-reported
- Reprogramming Method Viral transfection (Lentivirus: Oct4, Klf4, Sox2, cMyc)
- Tissue Origin Skin
- Genetic Alteration Mutation Information Duplication of the amyloid-beta precursor protein gene.
- Diagnosis Information Diagnosis of Familial Alzheimer's disease was physician reported. Age of diagnosis was 46 years.
- Disease Familial Alzheimer`s disease
- Ethnicity Caucasian > Nordic
- Genetic Alteration Mutation APP (duplication)
- Pubmed Abstract Israel, MA et al "Probing sporadic and familial Alzheimer`s disease using induced pluripotent stem cells" Nature 482.7384 (2012): 216-220
- Eagle-I UCSD236i-APP1-1
- Provider University of California, San Diego - Dr. Larry Goldstein
- Collections Alzheimer's disease
Lot Number | Culture Platform | Lot Description | Banked By | Passage Number | Protocol | Product Info URL |
WB66255 | Stem Cell Culture Medium (KOSR/MEF) | WiCell | 22 | WiCell Feeder Based (MEF) Pluripotent Stem Cell Protocol |
Lot Number | Culture Platform | Lot Description | Banked By | Protocol | Product Info URL |
DB26819 | Stem Cell Culture Medium (KOSR/MEF) | Provider | WiCell Feeder Based (MEF) Pluripotent Stem Cell Protocol |