NHLBI Next Gen - Left Ventricular Hypertrophy (Dr. Ulrich Broeckel, Medical College of Wisconsin)


About Broeckel Lab’s Next Gen Cell Lines

This collection, from Dr. Ulrich Broeckel (Medical College of Wisconsin), was generated to investigate the molecular mechanisms that underlie the genetic basis of left ventricular hypertrophy.   

This collection contains over 100 cell lines.  Donors for these iPSC lines are part of the Hypertension Genetic Epidemiology Network (HyperGEN).  Donors for this collection include both those with a diagnosis of left ventricular hypertrophy and controls (no disease reported).  The age of the donors ranges from 34-83 years, and ethnicities include Caucasian and African American.

Additional information regarding relationships can be found here.

About the Next Generation Genetic Association Studies (Next Gen) Program     

These cell lines were created as Next Generation Genetic Association Studies (Next Gen) Program, which was a five-year, $80 million program to investigate functional genetic variation in humans by assessing cellular profiles that are surrogates for disease phenotypes. To achieve this, researchers from multiple institutions across the U.S. were awarded grants to derive iPS cell lines from more than 1,500 individuals representing various conditions as well as healthy controls for use in functional genomic (‘disease in a dish’) research. This extensive panel includes a diverse set of age, gender and ethnic backgrounds, and therefore will be an invaluable tool for evaluations across demographics. Further enhancing the utility of these cell lines are data sets such as phenotyping, GWAS, genome sequencing, gene expression and -omics analyses (e.g., lipidomic, proteomic, methylomic) that will be made available with the cell lines.
Cell Lines 116 Cell Lines
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Cell Line Cell Line Alias Cell Type Disease Genetic Alteration/Mutation Sex Age at Collection Ethnicity Genetically Related Cell Lines dbGaP Data
MCW001i-40001487   Human iPS None reported    Male 53 Years Caucasian  Yes Yes
MCW002i-40001265   Human iPS None reported    Male 40 Years Caucasian  Yes Yes
MCW003i-40001883   Human iPS None reported    Male 53 Years Caucasian  Yes Yes
MCW004i-40002545   Human iPS None reported    Female 55 Years Caucasian  Yes Yes
MCW005i-40002552   Human iPS None reported    Female 66 Years Caucasian  Yes Yes
MCW006i-40000930   Human iPS None reported    Male 47 Years Caucasian  No Yes
MCW007i-U2456   Human iPS None reported    Male 73 Years Caucasian  No Yes
MCW008i-40000992   Human iPS None reported    Female 52 Years Caucasian  Yes Yes
MCW009i-40002262   Human iPS None reported    Female 55 Years Caucasian  Yes Yes
MCW010i-40000756   Human iPS None reported    Male 59 Years Caucasian  Yes Yes
Cell Lines 116 Cell Lines
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