About Broeckel Lab’s Next Gen Cell Lines

This collection, from Dr. Ulrich Broeckel (Medical College of Wisconsin), was generated to investigate the molecular mechanisms that underlie the genetic basis of left ventricular hypertrophy.

This collection contains over 100 cell lines. Donors for these iPSC lines are part of the Hypertension Genetic Epidemiology Network (HyperGEN). Donors for this collection include both those with a diagnosis of left ventricular hypertrophy and controls (no disease reported). The age of the donors ranges from 34-83 years, and ethnicities include Caucasian and African American.

Additional information regarding relationships can be found here.

About the Next Generation Genetic Association Studies (Next Gen) Program

These cell lines were created as Next Generation Genetic Association Studies (Next Gen) Program, which was a five-year, $80 million program to investigate functional genetic variation in humans by assessing cellular profiles that are surrogates for disease phenotypes. To achieve this, researchers from multiple institutions across the U.S. were awarded grants to derive iPS cell lines from more than 1,500 individuals representing various conditions as well as healthy controls for use in functional genomic (‘disease in a dish’) research. This extensive panel includes a diverse set of age, gender and ethnic backgrounds, and therefore will be an invaluable tool for evaluations across demographics. Further enhancing the utility of these cell lines are data sets such as phenotyping, GWAS, genome sequencing, gene expression and -omics analyses (e.g., lipidomic, proteomic, methylomic) that will be made available with the cell lines.