Alzheimer's disease Collection

Alzheimer’s disease pathogenesis investigation has historically been limited by difficulties in obtaining live neurons from patients and the inability to model the sporadic form of the disease.  In an effort to overcome these hurdles, primary fibroblasts were isolated and reprogrammed into iPS cell lines from two patients with familial Alzheimer’s disease, both caused by a duplication of the amyloid-β precursor protein gene1 (APP; termed APPDp); two with sporadic Alzheimer’s disease (termed sAD1, sAD2); and two non-demented control individuals.  A total of 13 iPS cell lines were derived from materials obtained from these individuals. 

The publication describing this collection of iPSCs may be found here.
Cell Lines 13 Cell Lines
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Cell Line Cell Line Alias Cell Type Disease Genetic Alteration/Mutation Sex Age at Collection Ethnicity Genetically Related Cell Lines dbGaP Data
UCSD223i-NDC1-1 NDC1.1 Human iPS None reported    Male 86 Years Caucasian  N/A No
UCSD224i-NDC1-2 NDC1.2 Human iPS None reported    Male 86 Years Caucasian  N/A No
UCSD225i-NDC1-3 NDC1.3 Human iPS None reported    Male 86 Years Caucasian  N/A No
UCSD226i-NDC2-1 NDC2.1 Human iPS None reported    Male 86 Years Caucasian, Latino  N/A No
UCSD228i-NDC2-3 NDC2.3 Human iPS None reported    Male 86 Years Caucasian, Latino  N/A No
UCSD229i-SAD1-1 SAD1.1 Human iPS Sporadic Alzheimer's disease    Female 83 Years Caucasian, Latino  N/A No
UCSD231i-SAD1-3 SAD1.3 Human iPS Sporadic Alzheimer's disease    Female 83 Years Caucasian, Latino  N/A No
UCSD233i-SAD2-2 SAD2.2 Human iPS Sporadic Alzheimer's disease    Male 83 Years Caucasian  N/A No
UCSD234i-SAD2-3 SAD2.3 Human iPS Sporadic Alzheimer's disease    Male 83 Years Caucasian  N/A No
UCSD236i-APP1-1 APP1.1 Human iPS Familial Alzheimer`s disease  APP (duplication)  Male 51 Years Caucasian > Nordic   N/A No
Cell Lines 13 Cell Lines
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