** This cell line contains an expected karyotypic abnormality consistent with the phenotype indicated in the "disease" field below. Please see the karyotype report in the Product Information & Testing PDF(s) linked below for more information.

This induced pluripotent stem (iPS) cell line, which serves as a model for Down Syndrome (Trisomy 21), was created by reprogramming a trisomy of 21 (Ts21) human fibroblast line. An additional clone from this iPS cell line (UWWC1-DS4) is available from WiCell.
Cell Line Alias DS1
Cell Type Human iPS
Disease Down syndrome, Trisomy 21
Genetic Alteration/Mutation 47,XY,+21 (Trisomy 21)
Sex Male
Age at Collection 1 Years
Genetically Related Cell Lines  
Reprogramming Method Viral transfection (Lentivirus: Oct4, Klf4, Sox2, cMyc)
Provider University of Wisconsin - Dr. Anita Bhattacharyya
dbGaP Data  
Eagle-I UID  
hPSCReg ID  
NIH Approval  
Pub Med Abstract  
Related Products
Collection(s) Down syndrome (Bhattacharyya) Collection
Have you received this cell line previously? Yes No Why we ask
Quantity: Learn about our volume discounts

Current Lot Information

Lot Number Culture Platform Lot Description Passage Number Banked By Protocol Product Information & Testing
WB21343 mTeSR™1/Matrigel™   27 WiCell WiCell Feeder Independent mTeSR™1 Protocol PDF